肌萎缩侧索硬化症认知行为筛查电话版（ALS-CBS™-PhV）：意大利人群样本的常模、心理测量学和诊断结果。
ALS Cognitive Behavioral Screen-Phone Version (ALS-CBS™-PhV): norms, psychometrics, and diagnostics in an Italian population sample.
机构信息
PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Department of Psychology, University of Milano-Bicocca, Milan, Italy.
出版信息
Neurol Sci. 2022 Apr;43(4):2571-2578. doi: 10.1007/s10072-021-05636-x. Epub 2021 Oct 2.
BACKGROUND
Up to 50% of motor neuron disease (MND) patients show neuropsychological deficits which negatively affect prognosis and care. However, disability-related logistical issues and uneven geographical coverage of healthcare services may prevent MND patients from accessing neuropsychological evaluations. This study thus aimed to standardize for the Italian population the ALS Cognitive Behavioral Screen-Phone Version (ALS-CBS™-PhV), an MND-specific, telephone-based screening for frontotemporal dysfunction.
METHODS
The cognitive section of the ALS-CBS™-PhV, the Italian telephone-based Mini-Mental State Examination (Itel-MMSE), and the Telephone Interview for Cognitive Status (TICS) was administered to 359 healthy individuals (143 males, 216 females; age, 52.7 ± 15.8; education, 13.1 ± 4.4). Norms were derived through equivalent scores. Validity, factorial structure, reliability, diagnostic accuracy, and item difficulty and discrimination were examined. Statistical equivalence between the telephone-based and in-person versions was tested.
RESULTS
ALS-CBS™-PhV measures were predicted by age and education. The ALS-CBS™-PhV reflected a mono-component structure, converged with Itel-MMSE and TICS scores (r = .23-.51) and was equivalent to its in-person format (t = .37; p = .72). Good internal (Cronbach's α = .61), test-retest (ICC = .69), and inter-rater (ICC = .96) reliability was detected. High accuracy was found when tested against both the Itel-MMSE and the TICS (AUC = .82-89). Backward digit span items were the most discriminative.
DISCUSSION
The ALS-CBS™-PhV is a statistically solid screening test for frontotemporal disorders featuring MND. Its standardization allows for (1) improvements in tele-healthcare for MND patients, (2) epidemiological applications, and (3) effective assessments in decentralized clinical trials. The ALS-CBS™-PhV can be also suitable for assessing bedridden and visually impaired patients with motor disorders.
背景
多达 50%的运动神经元病（MND）患者存在神经心理学缺陷，这对预后和护理产生负面影响。然而，残疾相关的后勤问题和医疗保健服务的不均衡地域覆盖可能会阻止 MND 患者接受神经心理学评估。因此，本研究旨在为意大利人群标准化 ALS 认知行为电话筛查版（ALS-CBS™-PhV），这是一种基于电话的 MND 特定的额颞叶功能障碍筛查工具。
方法
对 359 名健康个体（143 名男性，216 名女性；年龄 52.7±15.8；教育程度 13.1±4.4）进行 ALS-CBS™-PhV 的认知部分、基于电话的意大利式简易精神状态检查（Itel-MMSE）和电话认知状态检查（TICS）。通过等效分数得出常模。评估了有效性、因子结构、可靠性、诊断准确性以及项目难度和鉴别力。测试了电话和面对面版本之间的统计学等效性。
结果
ALS-CBS™-PhV 测量值受年龄和教育程度的影响。ALS-CBS™-PhV 反映了一个单一成分结构，与 Itel-MMSE 和 TICS 分数相关（r=0.23-0.51），与面对面形式等效（t=0.37；p=0.72）。内部一致性（Cronbach's α=0.61）、重测信度（ICC=0.69）和评分者间信度（ICC=0.96）均良好。在与 Itel-MMSE 和 TICS 进行测试时，其准确性均很高（AUC=0.82-0.89）。反向数字跨度项目的鉴别力最高。
讨论
ALS-CBS™-PhV 是一种针对 MND 患者额颞叶障碍的具有统计学意义的可靠筛查测试。其标准化允许：（1）改善 MND 患者的远程医疗；（2）开展流行病学应用；（3）在分散的临床试验中进行有效评估。ALS-CBS™-PhV 也适用于评估患有运动障碍的卧床不起和视力受损的患者。
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