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The chicken and egg problem: CGRP release due to trigeminal activation or vice versa?

作者信息

Messlinger Karl

机构信息

Institute of Physiology and Pathophysiology, Friedrich-Alexander-University, Erlangen-Nürnberg Universitätsstr. Erlangen, Germany.

出版信息

Cephalalgia. 2022 Mar;42(3):183-185. doi: 10.1177/03331024211042360. Epub 2021 Oct 4.

DOI:10.1177/03331024211042360
PMID:34601945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8988462/
Abstract
摘要

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The chicken and egg problem: CGRP release due to trigeminal activation or vice versa?先有鸡还是先有蛋的问题：是由于三叉神经激活导致降钙素基因相关肽（CGRP）释放，还是反之亦然？
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Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons.降钙素基因相关肽增强三叉神经节神经元释放内源性脑源性神经营养因子。
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PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor.促肾上腺皮质激素释放激素-38（PACAP-38）而非血管活性肠肽（VIP）通过一种不同于PAC1受体的受体诱导三叉神经尾侧核释放降钙素基因相关肽（CGRP）。
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Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks.唾液降钙素基因相关肽可监测不同偏头痛阶段：CGRP（依赖/不依赖）发作。
Cephalalgia. 2022 Mar;42(3):186-196. doi: 10.1177/03331024211040467. Epub 2021 Oct 4.
2
The trigeminal system: The meningovascular complex- A review.三叉神经系统：血管神经丛——综述。
J Anat. 2021 Jul;239(1):1-11. doi: 10.1111/joa.13413. Epub 2021 Feb 18.
3
Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls.与健康对照组相比，偏头痛患者的泪液中降钙素基因相关肽水平升高。
Cephalalgia. 2019 Oct;39(12):1535-1543. doi: 10.1177/0333102419856640. Epub 2019 Jun 10.
4
CGRP and the Trigeminal System in Migraine.降钙素基因相关肽与偏头痛的三叉神经系统。
Headache. 2019 May;59(5):659-681. doi: 10.1111/head.13529. Epub 2019 Apr 14.
5
Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal.血清 CGRP 测量作为慢性偏头痛生物标志物的可行性：批判性再评价。
J Headache Pain. 2018 Jul 13;19(1):53. doi: 10.1186/s10194-018-0883-x.
6
The CGRP Pathway in Migraine as a Viable Target for Therapies.偏头痛中 CGRP 通路作为一种可行的治疗靶点。
Headache. 2018 May;58 Suppl 1:33-47. doi: 10.1111/head.13305.
7
The big CGRP flood - sources, sinks and signalling sites in the trigeminovascular system.大 CGRP 洪流——三叉神经血管系统中的来源、汇点和信号位点。
J Headache Pain. 2018 Mar 12;19(1):22. doi: 10.1186/s10194-018-0848-0.
8
Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine.间歇期外周血 CGRP 水平升高可作为慢性偏头痛的生物标志物。
Neurology. 2013 Oct 1;81(14):1191-6. doi: 10.1212/WNL.0b013e3182a6cb72. Epub 2013 Aug 23.
9
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain.偏头痛发病机制：三叉血管通路解剖及相关神经症状、皮质扩散性抑制、敏化和疼痛调制。
Pain. 2013 Dec;154 Suppl 1:S44-53. doi: 10.1016/j.pain.2013.07.021. Epub 2013 Jul 25.
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Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura.降钙素基因相关肽可引发有先兆偏头痛患者偏头痛样发作。
Cephalalgia. 2010 Oct;30(10):1179-86. doi: 10.1177/0333102410368444. Epub 2010 May 12.