Division of Allergy/Immunology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3950 Beaubien, 4th Floor, Pediatric Specialty Building, Detroit, MI 48201, USA.
Division of Hospital Medicine, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.
Immunol Allergy Clin North Am. 2021 Nov;41(4):599-611. doi: 10.1016/j.iac.2021.07.002.
Inner-city children with asthma are known to have high disease mortality and morbidity. Frequently, asthma in this high-risk population is difficult to control and more severe in nature. Several factors, including socioeconomic hardship, ability to access to health care, adherence to medication, exposure to certain allergens, pollution, crowd environment, stress, and infections, play an important role in the pathophysiology of inner-city asthma. Comprehensive control of home allergens and exposure to tobacco smoke, the use of immune based therapies, and school-based asthma programs have shown promising results in asthma control in this population.
城市内哮喘儿童的疾病死亡率和发病率较高是众所周知的。在这一高危人群中,哮喘通常难以控制,且性质更为严重。多种因素,包括社会经济困难、获得医疗保健的能力、对药物的坚持使用、接触某些过敏原、污染、拥挤的环境、压力和感染,在城市内哮喘的病理生理学中发挥着重要作用。全面控制家庭过敏原和接触烟草烟雾、使用免疫治疗以及基于学校的哮喘计划,已显示出在该人群中控制哮喘方面有良好的效果。