CXCR5^+CD8^+ T 细胞：抗体调节功能及其临床相关性综述。
CXCR5CD8 T cells: A Review of their Antibody Regulatory Functions and Clinical Correlations.
机构信息
Medical Student Research Program, The Ohio State University College of Medicine, Columbus, OH.
Comprehensive Transplant Center, Department of Surgery, The Ohio State University, Columbus, OH; and.
出版信息
J Immunol. 2021 Jun 15;206(12):2775-2783. doi: 10.4049/jimmunol.2100082.
CD8 T cells have conventionally been studied in relationship to pathogen or tumor clearance. Recent reports have identified novel functions of CXCR5CD8 T cells that can home to lymphoid follicles, a key site of antibody production. In this review we provide an in-depth analysis of conflicting reports regarding the impact of CXCR5CD8 T cells on antibody production and examine the data supporting a role for antibody-enhancement (B cell "helper") and antibody-downregulation (antibody-suppressor) by CXCR5CD8 T cell subsets. CXCR5CD8 T cell molecular phenotypes are associated with CD8-mediated effector functions including distinct subsets that regulate antibody responses. Co-inhibitory molecule PD-1, among others, distinguish CXCR5CD8 T cell subsets. We also provide the first in-depth review of human CXCR5CD8 T cells in the context of clinical outcomes and discuss the potential utility of monitoring the quantity of peripheral blood or tissue infiltrating CXCR5CD8 T cells as a prognostic tool in multiple disease states.
CD8 T 细胞传统上被研究与病原体或肿瘤清除的关系。最近的报告确定了 CXCR5CD8 T 细胞的新功能，它们可以归巢到淋巴滤泡，这是抗体产生的关键部位。在这篇综述中，我们对关于 CXCR5CD8 T 细胞对抗体产生影响的相互矛盾的报告进行了深入分析，并研究了支持 CXCR5CD8 T 细胞亚群在抗体增强（B 细胞“辅助”）和抗体下调（抗体抑制）方面的作用的数据。CXCR5CD8 T 细胞的分子表型与 CD8 介导的效应功能相关，包括调节抗体反应的不同亚群。共抑制分子 PD-1 等可以区分 CXCR5CD8 T 细胞亚群。我们还首次深入综述了人类 CXCR5CD8 T 细胞在临床结局方面的情况，并讨论了监测外周血或组织浸润的 CXCR5CD8 T 细胞数量作为多种疾病状态的预后工具的潜在效用。
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