Lahousen M
Wien Klin Wochenschr. 1986 May 16;98(10):319-25.
The tumour markers carcinoembryonic antigen (CEA), ferritin, cancer antigen 125 (CA 125) and tissue polypeptide antigen (TPA) were measured by radioimmunoassay in sera from 80 patients with ovarian cancer pre-operatively, postoperatively, during cytostatic chemotherapy and on follow up. Discriminant analysis was applied to obtain retrospective classification of 60 patients into a group showing a favourable course of the disease (no recurrence, tumour regression) and into a group with an unfavourable course (recurrence, progression of the tumour). The classification was based on the introduction of the Cutting Score. By means of this bio-mathematical model it was possible to make at least a short-term prognostic statement in a further 20 patients. It is suggested that invasive diagnostic procedures may not be required in patients who are found to have normal tumour marker levels.
采用放射免疫分析法对80例卵巢癌患者术前、术后、细胞抑制化疗期间及随访时血清中的肿瘤标志物癌胚抗原（CEA）、铁蛋白、癌抗原125（CA125）和组织多肽抗原（TPA）进行了检测。采用判别分析方法，对60例患者进行回顾性分类，分为疾病进展良好组（无复发、肿瘤消退）和疾病进展不良组（复发、肿瘤进展）。分类基于切割分数的引入。通过这种生物数学模型，有可能对另外20例患者做出至少短期的预后判断。建议对于肿瘤标志物水平正常的患者，可能不需要进行侵入性诊断程序。
