Del Fiore Paolo, Russo Irene, Ferrazzi Beatrice, Monico Alessandro Dal, Cavallin Francesco, Filoni Angela, Tropea Saveria, Russano Francesco, Di Prata Claudia, Buja Alessandra, Collodetto Alessandra, Spina Romina, Carraro Sabrina, Cappellesso Rocco, Nicolè Lorenzo, Chiarion-Sileni Vanna, Pigozzo Jacopo, Dall'Olmo Luigi, Rastrelli Marco, Vecchiato Antonella, Benna Clara, Menin Chiara, Di Carlo Daniela, Bisogno Gianni, Dei Tos Angelo Paolo, Alaibac Mauro, Mocellin Simone
Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, IOV- IRCCS, Padua, Italy.
Division of Dermatology, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Front Oncol. 2021 Sep 16;11:725523. doi: 10.3389/fonc.2021.725523. eCollection 2021.
The "Veneto Cancer Registry" records melanoma as the most common cancer diagnosed in males and the third common cancer in females under 50 years of age in the Veneto Region (Italy). While melanoma is rare in children, it has greater incidence in adolescents and young adults (AYA), but literature offers only few studies specifically focused on AYA melanoma. The aim of this study was to describe the characteristics, surgical treatment, and prognosis of a cohort of AYA melanoma in order to contribute to the investigation of this malignancy and provide better patient care. This retrospective cohort study included 2,752 Caucasian patients (702 AYA and 2,050 non-AYA patients) from the Veneto Region who were over 15 years of age at diagnosis, and who received diagnosis and/or treatment from our institutions between 1998 and 2014. Patients were divided in adolescents and youth (15-25 years), young adults (26-39 years) and adults (more than 39 years) for the analysis. We found statistically significant differences in gender, primary site, Breslow thickness, ulceration, pathologic TNM classification (pTNM) stage and tumor subtype among the age groups. Disease-specific survival and disease-free survival were also different among the age groups. Our findings suggest that the biological behavior of melanoma in young people is different to that in adults, but not such as to represent a distinct pathological entity. Additional and larger prospective studies should be performed to better evaluate potential biological and cancer-specific differences between AYAs and the adult melanoma population.
“威尼托癌症登记处”记录显示，黑色素瘤是意大利威尼托地区诊断出的男性最常见癌症，也是50岁以下女性中第三常见的癌症。虽然黑色素瘤在儿童中罕见，但在青少年和青年（AYA）中发病率较高，不过文献中专门针对AYA黑色素瘤的研究较少。本研究的目的是描述一组AYA黑色素瘤的特征、手术治疗及预后情况，以促进对这种恶性肿瘤的研究，并提供更好的患者护理。这项回顾性队列研究纳入了来自威尼托地区的2752名白种人患者（702名AYA患者和2050名非AYA患者），他们在诊断时年龄超过15岁，且在1998年至2014年间在我们机构接受了诊断和/或治疗。为进行分析，将患者分为青少年和青年（15 - 25岁）、青年成人（26 - 39岁）和成人（39岁以上）。我们发现不同年龄组在性别、原发部位、Breslow厚度、溃疡、病理TNM分类（pTNM）分期和肿瘤亚型方面存在统计学上的显著差异。不同年龄组的疾病特异性生存率和无病生存率也有所不同。我们的研究结果表明，年轻人黑色素瘤的生物学行为与成年人不同，但并非代表一种独特的病理实体。应开展更多更大规模的前瞻性研究，以更好地评估AYA患者与成年黑色素瘤患者之间潜在的生物学和癌症特异性差异。
