多态性及其与日本男性前列腺癌风险的关联。
polymorphisms and their association with prostate cancer risk in Japanese men.
机构信息
Department of Public Health, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
出版信息
J Prev Med Hyg. 2021 Jul 30;62(2):E489-E495. doi: 10.15167/2421-4248/jpmh2021.62.2.1865. eCollection 2021 Jun.
INTRODUCTION
Prostate cancer (PCa) is one of the most common cancers affecting men globally. Although PER3 has been suggested as a risk factor for cancer development, there are few reports elucidating the relationship between PER3 and PCa. We investigated the association between PER3 polymorphisms (rs2640908 and VNTR) and susceptibility to PCa in the Japanese population.
METHODS
Eighty three patients with PCa and 122 controls participated in this study. We analyzed rs2640908 and VNTR polymorphisms by using PCR-Restriction Fragment Length Polymorphism (PCR-RFLP).
RESULTS
Compared to the C/C genotype with the rs2640908 polymorphism, the T/T (OR: 0.35, 95% CI: 0.15-0.81, P = 0.02) and C/T + T/T (OR: 0.46, 95% CI: 0.24-0.88, P = 0.02) genotypes had a significantly lower risk of PCa. TT (OR: 0.29, 95% CI: 0.10-0.77, P = 0.02) and CT + TT (OR: 0.47, 95% CI: 0.23-0.97, P = 0.04) also had significant protection against PCa in the smoker group. Significantly, we observed an association between smoking and rs2640908 polymorphism in this study. However, no association between the VNTR polymorphisms and PCa was detected.
CONCLUSIONS
Our results suggest that PER3 rs2640908 polymorphisms influence an individual's susceptibility to PCa.
简介
前列腺癌（PCa）是全球男性最常见的癌症之一。尽管 PER3 已被认为是癌症发展的风险因素，但鲜有研究阐明 PER3 与 PCa 之间的关系。我们研究了 PER3 多态性（rs2640908 和 VNTR）与日本人 PCa 易感性之间的关系。
方法
本研究纳入 83 例 PCa 患者和 122 例对照。我们采用 PCR-限制性片段长度多态性（PCR-RFLP）分析 rs2640908 和 VNTR 多态性。
结果
与 rs2640908 多态性的 C/C 基因型相比，T/T（OR：0.35，95%CI：0.15-0.81，P = 0.02）和 C/T + T/T（OR：0.46，95%CI：0.24-0.88，P = 0.02）基因型患 PCa 的风险显著降低。TT（OR：0.29，95%CI：0.10-0.77，P = 0.02）和 CT + TT（OR：0.47，95%CI：0.23-0.97，P = 0.04）基因型在吸烟者中也对 PCa 具有显著保护作用。此外，我们还观察到本研究中 rs2640908 多态性与吸烟之间存在关联。然而，VNTR 多态性与 PCa 之间无关联。
结论
我们的研究结果表明，PER3 rs2640908 多态性影响个体患 PCa 的易感性。
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