Role of the period family in mediating the interplay between circadian disruption and cancer (Review).

The circadian clock, which is based on 24-h cyclical changes in the external environment, can be detected in almost all cells and regulates several vital physiological processes. The circadian rhythm is disrupted in numerous individuals for several reasons, such as shift work, chronic jet lag, high fat intake and abnormal sleep patterns. Disruption of the circadian rhythm can increase the risk of cancer, affecting its development and treatment. The Period gene family is a core component of the circadian rhythm cycle, and the mechanisms by which its changes affect cancer progression are unclear. The present study reviewed the current research on the intricate relationship between disruption of the circadian clock, particularly focusing on the Period gene family, and its effect on the occurrence, progression and therapeutic approaches for cancer.