NMR 测定细胞内药物结合亲和力。
Intracellular drug binding affinities by NMR.
机构信息
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, Neue Stiftingtalstrasse 6/VI, 8010 Graz, Austria.
出版信息
Acta Crystallogr D Struct Biol. 2021 Oct 1;77(Pt 10):1216-1217. doi: 10.1107/S2059798321010135.
Abstract
A commentary on the article by Luchinat [(2021), D, 1247–1258] where they describe an approach to identify the details of a compound binding to a molecular target using in-cell NMR to provide intracellular binding affinities.
摘要
卢奇纳特等人在文章中描述了一种使用细胞内 NMR 来鉴定化合物与分子靶标结合细节的方法，以提供细胞内结合亲和力。评注
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