英夫利昔单抗治疗儿童中枢神经系统结核的矛盾反应。
Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis.
机构信息
Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
出版信息
J Pediatric Infect Dis Soc. 2021 Dec 31;10(12):1087-1091. doi: 10.1093/jpids/piab094.
Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.
中枢神经系统结核（CNS-TB）中的矛盾反应与较高的发病率和死亡率相关。我们描述了 4 例 HIV 阴性、接受 CNS-TB 治疗的儿童出现严重矛盾反应，对皮质类固醇无反应。所有患儿在使用英夫利昔单抗治疗后均康复，这突显了英夫利昔单抗治疗该并发症的安全性和有效性，需要前瞻性试验。
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