Alonso I G, Mariño E L, Dominguez-Gil A, Tabernero J M
Int J Clin Pharmacol Ther Toxicol. 1986 Jul;24(7):359-61.
In a study in which i.v. bolus injections of cefotiam were administered at a dose of 1000 mg directly before the start of hemofiltration sessions, the purification capacity of the drug was seen to be similar to that of other cephalosporins. Hemofiltration did not completely restore normal renal function, though it was only slightly less efficient with mean values and standard deviations for the extraction coefficient (E.C.) and hemofiltration clearance (Clh) of 0.25 +/- 0.06 and 74.02 +/- 17.05 ml/min, respectively.
在一项研究中，在血液滤过治疗开始前直接静脉推注1000毫克头孢替安，该药物的清除能力与其他头孢菌素相似。血液滤过并未完全恢复正常肾功能，尽管其效率略低，提取系数（E.C.）和血液滤过清除率（Clh）的平均值和标准差分别为0.25±0.06和74.02±17.05毫升/分钟。
