Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
J Pediatr Adolesc Gynecol. 2022 Apr;35(2):177-181. doi: 10.1016/j.jpag.2021.09.005. Epub 2021 Oct 2.
Extragonadal yolk sac tumors (YSTs) occurring in the uterus are extremely rare. To report a uterine YST case in a prepubertal girl and review literature on uterine YST to outline clinical management in diagnosis and treatment.
We present a case of a 2-year-old girl who presented with vaginal bleeding and a pelvic mass. The diagnosis of YST was confirmed via biopsy. After four cycles of neoadjuvant chemotherapy combined with cisplatin, etoposide, and bleomycin (PEB), vaginoscopic examination and laparoscopy revealed a uterine YST without metastasis. The patient was treated with laparoscopic hysterectomy and two cycles of PEB postoperatively. During the 18 months of follow-up, the patient remained disease-free.
Primary uterine YST is extremely rare and no treatment guidelines have been established to date. Surgery combined with PEB chemotherapy is considered effective for uterine YST.
发生在子宫内的卵巢外卵黄囊瘤（YST）极为罕见。本文报告一例发生于青春期前女孩的子宫 YST，并对子宫 YST 文献进行复习，以总结其在诊断和治疗方面的临床管理要点。
我们报告了一例 2 岁女孩，因阴道出血和盆腔肿块就诊。通过活检确诊为 YST。在接受新辅助化疗联合顺铂、依托泊苷和博来霉素（PEB）四个周期后，阴道镜检查和腹腔镜检查显示子宫 YST 无转移。患者接受了腹腔镜子宫切除术和术后两个周期的 PEB 治疗。在 18 个月的随访期间，患者无疾病复发。
原发性子宫 YST 极为罕见，目前尚未制定出治疗指南。手术联合 PEB 化疗被认为对子宫 YST 有效。
