Liu Qiang, Dong Yanbo, Yuan Shuoqing, Yu Minghang, Liu Liangfa, Zhang Qing
Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Open Med (Wars). 2021 Sep 16;16(1):1395-1402. doi: 10.1515/med-2021-0356. eCollection 2021.
Voltage-dependent calcium channel subunit alpha-2/delta-1 (α2δ1) has been identified as a marker of cancer stem cells in multiple malignant tumor types. However, α2δ1's role in the prognosis of hypopharyngeal squamous cell carcinoma (HSCC) was not reported. In our study, ten pairs of HSCC and peritumoral normal tissues were used for immunohistochemistry assessment. And α2δ1 expression levels of 34 more HSCC samples were also evaluated, represented by the integral optic density using Image-Pro Plus. Clinicopathological associations and prognostic value of α2δ1 were analyzed. As a result, α2δ1 expression was frequently increased in HSCC tissues. Although the correlation between patients' clinicopathological characteristics and their α2δ1 expression levels was not significant, α2δ1 expression was significantly correlated with unfavorable overall survival (OS) ( = 0.018) and progression-free survival (PFS) ( = 0.023). Univariate and multivariate cox regression analyses suggested α2δ1's prognostic role for both OS and PFS ( = 0.013 and 0.011, respectively). This study specifically demonstrated that α2δ1 regularly increased in HSCC compared with peritumoral tissues, and α2δ1 could act as a promising prognostic marker in HSCC patients.
电压依赖性钙通道亚基α-2/δ-1（α2δ1）已被确定为多种恶性肿瘤类型中癌症干细胞的标志物。然而，α2δ1在下咽鳞状细胞癌（HSCC）预后中的作用尚未见报道。在我们的研究中，使用10对HSCC组织和瘤旁正常组织进行免疫组织化学评估。另外还评估了34个HSCC样本的α2δ1表达水平，采用Image-Pro Plus软件通过积分光密度来表示。分析了α2δ1的临床病理相关性及预后价值。结果显示，HSCC组织中α2δ1表达常常升高。虽然患者临床病理特征与其α2δ1表达水平之间的相关性不显著，但α2δ1表达与不良总生存期（OS）（P = 0.018）和无进展生存期（PFS）（P = 0.023）显著相关。单因素和多因素cox回归分析表明α2δ1对OS和PFS均具有预后作用（分别为P = 0.013和0.011）。本研究特别表明，与瘤旁组织相比，HSCC中α2δ1表达经常升高，并且α2δ1可作为HSCC患者有前景的预后标志物。
