Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, Juiz de Fora, MG, 36036-900, Brazil.
Grupo de Química Analítica e Quimiometria (GQAQ), Departamento de Química, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, Juiz de Fora, MG, 36036-900, Brazil.
Anal Methods. 2021 Oct 14;13(39):4557-4584. doi: 10.1039/d1ay01173a.
Malaria is a life-threatening disease being treated by oral medication. This is the best treatment to reduce morbidity and mortality, prevent disease progression to the most severe form, lower the transmission of the disease and hinder the appearance of strains resistant to antimalarials. According to the World Health Organization, the most common antimalarial drugs are chloroquine, primaquine, mefloquine, lumefantrine, artemether, and artesunate in single dosage forms or fixed-dose combination. Within this context, the present review aims to show the evolution of different analytical methods that have been applied to the determination of these antimalarial drugs in pharmaceutical formulations and human blood by liquid chromatography in the last 10 years, along with statistical analyses of the methods.
疟疾是一种危及生命的疾病，通过口服药物进行治疗。这是降低发病率和死亡率、防止疾病向最严重形式发展、降低疾病传播并阻碍抗疟药物耐药株出现的最佳治疗方法。根据世界卫生组织的数据，最常见的抗疟药物是氯喹、伯氨喹、甲氟喹、青蒿琥酯、蒿甲醚和青蒿琥酯，以单一剂量形式或固定剂量组合形式存在。在此背景下，本综述旨在展示过去 10 年中，通过液相色谱法在药物制剂和人血中测定这些抗疟药物的不同分析方法的演变，并对这些方法进行统计分析。
