Department of Pharmacology, Faculty of Basic Medical Sciences, PAMO University of Medical Sciences, Port-Harcourt, Nigeria.
Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Nsuka, Nigeria.
Biomarkers. 2021 Dec;26(8):718-725. doi: 10.1080/1354750X.2021.1990408. Epub 2021 Oct 24.
Oxido-inflammatory stress has been implicated as the main targets in alleviating diabetic complications induced by hyperglycaemia. : a bioactive plant serves great medicinal benefits in ethnopharmacology to ameliorate pathological conditions. This study investigated the protective effects of ethanol extract of (EEDD) in alloxan-induced diabetic rats through mechanism involving inhibition of oxidative stress and liver and kidney inflammatory markers.
Male Wistar rats were made diabetic via alloxan monohydrate (100 mg/kg) administration intraperitoneally. Diabetic rats were post-treated with EEDD (800 mg/kg) and Metformin (50 mg/kg) orally for two weeks. Fasting blood sugar (FBS), body and organ weight change, markers of oxidative stress, liver and kidney inflammation were evaluated.
Our results revealed that EEDD significantly reduced alloxan-induced hyperglycaemia in the diabetic rats after 5, 10 and 15 days of treatment. Markers of oxidative injury were also significantly ameliorated in the pancreas, liver and kidney of the diabetic rats following treatment with EEDD. However, liver and kidney injury markers were significantly attenuated with marked decreased organ weight in the diabetic rats after treatment with EEDD.
Here in, we found that could be used as nutraceuticals in the prevention and treatment of diabetes and its related complications through positively modulating oxidative stress and liver and kidney inflammatory markers.
氧化应激已被认为是减轻高血糖引起的糖尿病并发症的主要靶点。[一种具有生物活性的植物在民族药理学中具有很大的药用价值，可以改善病理状况。本研究通过抑制氧化应激和肝、肾炎症标志物，研究了（EEDD）乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的保护作用。
雄性 Wistar 大鼠通过腹腔注射一水合四氧嘧啶（100mg/kg）制成糖尿病模型。糖尿病大鼠用 EEDD（800mg/kg）和二甲双胍（50mg/kg）口服治疗两周。检测空腹血糖（FBS）、体质量和器官质量变化、氧化应激标志物、肝肾功能炎症标志物。
我们的结果表明，EEDD 可显著降低糖尿病大鼠在治疗 5、10 和 15 天后的高血糖。EEDD 还可显著改善糖尿病大鼠胰腺、肝脏和肾脏的氧化损伤标志物。然而，EEDD 治疗后可显著减轻糖尿病大鼠的肝、肾损伤标志物，并显著降低器官重量。
本研究发现，可作为天然药物用于预防和治疗糖尿病及其相关并发症，通过正向调节氧化应激和肝、肾炎症标志物。
