Enchev Venelin, Slavova Sofia
Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Phys Chem Chem Phys. 2021 Sep 14;23(34):19043-19053. doi: 10.1039/d1cp02158c. Epub 2021 Aug 24.
Reaction pathway of prebiotic reactions for formation of the pteridines: pterin, xanthopterine, isoxanthopterine and leucopterine, as well as the purine nucleobase guanine from pure formamide are presented. In these reactions, formamide or its tautomer, formimidic acid, play the role of proton-carrying catalyst. All required raw materials, such as hydrogen cyanide, ammonia, water, formic acid, urea, 2-aminomalononitrile, glyoxal, glyoxylic acid and oxalic acid needed in the self-catalyzed reactions are obtained by partial decomposition of formamide. We show that the prebiotic formation of nucleobases and pterins is closely linked and they probably coexisted at the beginning of chemical evolution.
展示了从纯甲酰胺形成蝶啶（蝶呤、黄蝶呤、异黄蝶呤和白蝶呤）以及嘌呤核碱基鸟嘌呤的益生元反应途径。在这些反应中，甲酰胺或其互变异构体甲亚胺酸充当质子携带催化剂。自催化反应所需的所有原材料，如氰化氢、氨、水、甲酸、尿素、2-氨基丙二腈、乙二醛、乙醛酸和草酸，都是通过甲酰胺的部分分解获得的。我们表明，核碱基和蝶呤的益生元形成紧密相连，它们可能在化学进化开始时就共存了。
