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无条件现金转移与脂基营养素补充剂和/或行为改变沟通相结合预防巴基斯坦儿童发育迟缓的效果:一项整群随机对照试验。

Effectiveness of unconditional cash transfers combined with lipid-based nutrient supplement and/or behavior change communication to prevent stunting among children in Pakistan: a cluster randomized controlled trial.

机构信息

Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan.

出版信息

Am J Clin Nutr. 2022 Feb 9;115(2):492-502. doi: 10.1093/ajcn/nqab341.

Abstract

BACKGROUND

In Pakistan, the prevalence of stunting among children younger than 5 y has remained above WHO critical thresholds (≥30%) over the past 2 decades.

OBJECTIVES

We hypothesized that an unconditional cash transfer (UCT) combined with lipid-based nutrient supplement (LNS) and/or social and behavior change communication (SBCC) will prevent stunting among children 6-23 mo of age.

METHODS

This was a 4-arm, community-based cluster randomized controlled trial conducted in the district of Rahim Yar Khan, Pakistan. A total of 1729 children (UCT, n = 434; UCT + SBCC, n = 433; UCT + LNS, n = 430; and UCT + LNS + SBCC, n = 432) were enrolled at 6 mo of age and measured monthly for 18 mo until the age of 24 mo.

RESULTS

At 24 mo of age, children who received UCT + LNS [rate ratio (RR): 0.85; 95% CI: 0.74, 0.97; P = 0.015) and UCT + LNS + SBCC (RR: 0.86; 95% CI: 0.77, 0.96; P = 0.007) had a significantly lower risk of being stunted compared with the UCT arm. No significant difference was noted among children who received UCT + SBCC (RR: 1.03; 95% CI: 0.91, 1.16; P = 0.675) in the risk of being stunted compared with the UCT arm. The pooled prevalence of stunting among children aged 6-23 mo was 41.7%, 44.8%, 38.5%, and 39.3% in UCT, UCT + SBCC, UCT + LNS, and UCT + LNS + SBCC, respectively. In pairwise comparisons, a significant impact on stunting among children in UCT + LNS (P = 0.029) and UCT + LNS + SBCC (P = <0.001) was noted compared with the UCT arm.

CONCLUSIONS

UCT combined with LNS and UCT + LNS + SBCC were effective in reducing the prevalence of stunting among children aged 6-23 mo in marginalized populations. UCT + SBCC was not effective in reducing the child stunting prevalence. This trial was registered at clinicaltrials.gov as NCT03299218.

摘要

背景

在过去的 20 年中,巴基斯坦 5 岁以下儿童发育迟缓的患病率一直高于世界卫生组织的临界阈值(≥30%)。

目的

我们假设无条件现金转移(UCT)与脂质基营养素补充剂(LNS)和/或社会和行为改变沟通(SBCC)相结合将预防 6-23 月龄儿童发育迟缓。

方法

这是一项在巴基斯坦拉希姆亚尔汗地区进行的 4 臂、基于社区的随机对照试验。共有 1729 名儿童(UCT 组,n=434;UCT+SBCC 组,n=433;UCT+LNS 组,n=430;UCT+LNS+SBCC 组,n=432)在 6 月龄时入组,并在 18 个月龄时每月测量一次,直到 24 月龄。

结果

在 24 月龄时,接受 UCT+LNS 治疗的儿童(RR:0.85;95%CI:0.74,0.97;P=0.015)和 UCT+LNS+SBCC 治疗的儿童(RR:0.86;95%CI:0.77,0.96;P=0.007)发育迟缓的风险明显低于 UCT 组。接受 UCT+SBCC 治疗的儿童(RR:1.03;95%CI:0.91,1.16;P=0.675)与 UCT 组相比,发育迟缓的风险没有显著差异。在 6-23 月龄儿童中,UCT、UCT+SBCC、UCT+LNS 和 UCT+LNS+SBCC 组的发育迟缓患病率分别为 41.7%、44.8%、38.5%和 39.3%。在两两比较中,UCT+LNS(P=0.029)和 UCT+LNS+SBCC(P<0.001)组儿童的发育迟缓发生率有显著影响。

结论

UCT 联合 LNS 和 UCT+LNS+SBCC 可有效降低边缘人群中 6-23 月龄儿童发育迟缓的发生率。UCT+SBCC 不能有效降低儿童发育迟缓的发生率。该试验在 clinicaltrials.gov 注册,编号为 NCT03299218。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7d/8827069/de403d58262d/nqab341fig1.jpg

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