令人惊叹的 cN-II，让我们忙碌不停的酶。

The amazing cN-II, the enzyme that keeps us busy.

机构信息

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, 69008, France.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2022;41(3):239-246. doi: 10.1080/15257770.2021.1983828. Epub 2021 Oct 6.

DOI:10.1080/15257770.2021.1983828

Abstract

cN-II is a cytosolic 5'-nucleotidase with preference for IMP and GMP over AMP. The enzyme has been extensively studied over the last 20-30 years both for its enzymatic activity, structure, role in nucleotide metabolism and in cell biology, as well as in diseases. With the aim of highlighting the complexity of the enzyme, I will, as during PP21, present work from our group and others working on cN-II and its various roles and not give an exhaustive overview of new data.

摘要

cN-II 是一种胞质 5'-核苷酸酶，对 IMP 和 GMP 的偏好超过 AMP。在过去的 20-30 年中，该酶因其酶活性、结构、在核苷酸代谢和细胞生物学中的作用以及在疾病中的作用而得到了广泛的研究。为了突出该酶的复杂性，我将像在 PP21 期间一样，展示我们小组和其他研究 cN-II 及其各种作用的小组的工作，而不是对新数据进行详尽的概述。

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