Przybyszewska M, Szaniawska B, Janik P
Neoplasma. 1986;33(3):341-4.
The aim of the study was to analyze the incidence of spontaneous thymic lymphomas in AKR mice kept on a diet with normal and excess retinoid content. The mice whose diet was supplemented with 13-cis-retinoic acid (250 mg per kg chow) developed less lymphomas than those kept on a standard diet (15 mg per kg chow). The effect of cyclophosphamide on the early stage of lymphomogenesis was tested using a single dose (100 mg per kg body weight), injected intraperitoneally to AKR mice. Increased incidence of lymphoma following cyclophosphamide administration was observed as result of a) low sensitivity of prelymphoma and lymphoma cells and/or b) immunosuppressive effect of cyclophosphamide.
本研究的目的是分析食用正常和过量视黄醇含量饮食的AKR小鼠自发性胸腺淋巴瘤的发病率。饮食中添加了13-顺式视黄酸（每千克食物250毫克）的小鼠比食用标准饮食（每千克食物15毫克）的小鼠发生淋巴瘤的情况更少。使用单次剂量（每千克体重100毫克）腹腔注射给AKR小鼠，测试了环磷酰胺对淋巴瘤发生早期阶段的影响。观察到给予环磷酰胺后淋巴瘤发病率增加，这是由于a）淋巴瘤前期细胞和淋巴瘤细胞的低敏感性和/或b）环磷酰胺的免疫抑制作用。
