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构建和分析直肠癌相关 lncRNA-mRNA ceRNA 网络揭示直肠癌的预后生物标志物。

Construction and characterization of rectal cancer-related lncRNA-mRNA ceRNA network reveals prognostic biomarkers in rectal cancer.

机构信息

Department of Integrative Medicine & Medical Oncology, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University, Shengzhou Branch), Shengzhou, Zhejiang, China.

出版信息

IET Syst Biol. 2021 Aug;15(6):192-204. doi: 10.1049/syb2.12035. Epub 2021 Oct 6.

DOI:10.1049/syb2.12035
PMID:34613665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8675822/
Abstract

Rectal cancer is an important cause of cancer-related deaths worldwide. In this study, the differentially expressed (DE) lncRNAs/mRNAs were first identified and the correlation level between DE lncRNAs and mRNAs were calculated. The results showed that genes of highly correlated lncRNA-mRNA pairs presented strong prognosis effects, such as GPM6A, METTL24, SCN7A, HAND2-AS1 and PDZRN4. Then, the rectal cancer-related lncRNA-mRNA network was constructed based on the ceRNA theory. Topological analysis of the network revealed that the network was maintained by hub nodes and a hub subnetwork was constructed, including the hub lncRNA MIR143HG and MBNL1-SA1. Further analysis indicated that the hub subnetwork was highly related to cancer pathways, such as 'Focal adhesion' and 'Wnt signalling pathway'. Hub subnetwork also had significant prognosis capability. A closed lncRNA-mRNA module was identified by bilateral network clustering. Genes in modules also showed high prognosis effects. Finally, a core lncRNA-TF crosstalk network was identified to uncover the crosstalk and regulatory mechanisms of lncRNAs and TFs by integrating ceRNA crosstalks and TF binding affinities. Some core genes, such as MEIS1, GLI3 and HAND2-AS1 were considered as the key regulators in tumourigenesis. Based on the authors' comprehensive analysis, all these lncRNA-mRNA crosstalks provided promising clues for biological prognosis of rectal cancer.

摘要

直肠癌是全球癌症相关死亡的重要原因。本研究首先鉴定差异表达（DE）lncRNA/mRNA，计算 DE lncRNA 和 mRNAs 之间的相关水平。结果表明，高相关 lncRNA-mRNA 对预后有强烈影响，如 GPM6A、METTL24、SCN7A、HAND2-AS1 和 PDZRN4。然后，基于 ceRNA 理论构建直肠癌相关 lncRNA-mRNA 网络。网络拓扑分析表明，网络由枢纽节点维持，并构建了一个枢纽子网，包括枢纽 lncRNA MIR143HG 和 MBNL1-SA1。进一步分析表明，枢纽子网与癌症途径高度相关，如“粘着斑”和“Wnt 信号通路”。枢纽子网也具有显著的预后能力。通过双边网络聚类识别封闭的 lncRNA-mRNA 模块。模块中的基因也表现出高预后效果。最后，通过整合 ceRNA 串扰和 TF 结合亲和力，鉴定了核心 lncRNA-TF 串扰网络，以揭示 lncRNAs 和 TFs 的串扰和调控机制。一些核心基因，如 MEIS1、GLI3 和 HAND2-AS1，被认为是肿瘤发生的关键调节因子。基于作者的综合分析，所有这些 lncRNA-mRNA 串扰为直肠癌的生物学预后提供了有前途的线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da2e/8675822/2200460dd13e/SYB2-15-192-g003.jpg
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3
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