一种新型钯芳环配合物，可作为空气和热稳定的氧化加成配合物前体。
A Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.
出版信息
Org Lett. 2021 Oct 15;23(20):7927-7932. doi: 10.1021/acs.orglett.1c02307. Epub 2021 Oct 6.
Abstract
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report the use of Cámpora's palladacycle as a new, more stable precursor to Pd OACs. Using this palladacycle, a series of biarylphosphine ligated OACs, including those with pharmaceutical-derived aryl halides and relevance to bioconjugation, were prepared.
摘要
孤立钯氧化加成配合物（OACs）的利用对 Pd 催化和 Pd 介导的交叉偶联反应产生了重大影响。尽管它们很重要，但 OACs 的广泛应用受到其前体配合物不稳定性的限制。在此，我们报告了使用 Cámpora 的钯环作为一种新的、更稳定的 Pd OAC 前体的用途。使用这种钯环，制备了一系列双芳基膦配位的 OACs，包括那些带有药物衍生的芳基卤化物和与生物偶联相关的 OACs。
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