Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Crit Rev Food Sci Nutr. 2023;63(18):3168-3188. doi: 10.1080/10408398.2021.1985428. Epub 2021 Oct 6.
Alzheimer's disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment. Some natural products and bioactive compounds from natural sources show great potential in the prevention and treatment of AD, such as apple, blueberries, grapes, chili pepper, , cruciferous vegetables, , , , sea cucumber, , green tea, Puer tea, and , via reducing amyloid beta (Aβ) deposition, decreasing Tau hyperphosphorylation, regulating cholinergic system, reducing oxidative stress, inhibiting apoptosis and ameliorating inflammation. This review mainly summarizes the effects of some natural products and their bioactive compounds on AD with the potential molecular mechanisms.
阿尔茨海默病（AD）是老年人最常见的痴呆症形式，发病率高，发病机制复杂，导致进行性认知功能障碍和记忆损伤。一些来自天然来源的天然产物和生物活性化合物在 AD 的预防和治疗方面显示出巨大的潜力，如苹果、蓝莓、葡萄、辣椒、十字花科蔬菜、大蒜、洋葱、海参、绿茶、普洱茶等，通过减少β淀粉样蛋白（Aβ）沉积、减少 Tau 过度磷酸化、调节胆碱能系统、减少氧化应激、抑制细胞凋亡和改善炎症来发挥作用。本综述主要总结了一些天然产物及其生物活性化合物对 AD 的作用及其潜在的分子机制。
