Bae Kyung-Nam, Shin Kihyuk, Kim Hoon-Soo, Kim Byung-Soo, Kim Moon-Bum, Ko Hyun-Chang
Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.
Department of Dermatology, Pusan National University Yangsan Hospital, Busan, Korea.
Ann Dermatol. 2021 Oct;33(5):448-455. doi: 10.5021/ad.2021.33.5.448. Epub 2021 Sep 8.
A minority of infantile hemangiomas showing minimal or arrested growth (IH-MAGs) have been recognized in the literature. Nevertheless, the clinical features and treatment outcomes of IH-MAGs have not been well investigated.
This study aimed to understand the clinical characteristics of IH-MAGs better and their response to treatment with topical timolol maleate.
We retrospectively reviewed medical records and clinical images of patients with IH-MAGs. Treatment response with topical timolol was assessed in both IH-MAGs and classic infantile hemangiomas (IHs) groups.
Of the 1,038 patients with IHs, only 31 (3.0%) were diagnosed with IH-MAGs. Lesions with non-proliferative components were more frequently distributed in the lower half of the body (61.5%) than those with proliferative components (16.7%). In 14 patients treated with topical timolol, the global assessment scale showed more significant and rapid improvement than in those with classic IHs.
Although the prevalence of IH-MAGs may be relatively low, understanding their clinical features will help in differential diagnosis. Furthermore, these type of lesions might be more responsive to topical timolol than classic IHs.
文献中已认识到少数显示最小或停止生长的婴儿血管瘤（IH-MAGs）。然而，IH-MAGs的临床特征和治疗结果尚未得到充分研究。
本研究旨在更好地了解IH-MAGs的临床特征及其对局部使用马来酸噻吗洛尔治疗的反应。
我们回顾性分析了IH-MAGs患者的病历和临床图像。评估了IH-MAGs组和经典婴儿血管瘤（IHs）组局部使用噻吗洛尔的治疗反应。
在1038例IHs患者中，只有31例（3.0%）被诊断为IH-MAGs。具有非增殖成分的病变在下半身的分布（61.5%）比具有增殖成分的病变（16.7%）更频繁。在14例接受局部使用噻吗洛尔治疗的患者中，整体评估量表显示比经典IHs患者有更显著和快速的改善。
尽管IH-MAGs的患病率可能相对较低，但了解其临床特征将有助于鉴别诊断。此外，这类病变可能比经典IHs对局部使用噻吗洛尔更敏感。
