Alshamsi Shaikha, Hamidi Samer, Ozgen Narci Hacer
School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates.
School of Health and Environment Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates.
Clinicoecon Outcomes Res. 2021 Sep 29;13:853-862. doi: 10.2147/CEOR.S334724. eCollection 2021.
The aim of this study was to assess the indirect burden of patients with transfusion-dependent thalassemia (TDT) in Dubai, the United Arab Emirates (UAE).
Adult patients with TDT were enrolled during blood transfusion sessions. Productivity loss for patients in the preceding four weeks was reported using the validated iMTA Productivity Cost Questionnaire (iPCQ).
A total of 161 adult patients with TDT were included in the study. The annual total productivity loss cost at paid work among 79 employed patients was AED 17,230 (USD 4691) (95% CI: 12,302-22,159), out of which absenteeism contributed AED 10,328 (USD 2812) and presenteeism contributed AED 6902 (USD 1879), whereas the annual total productivity loss cost at unpaid work was AED 4053 (USD 1104) (95% CI: 3471-4661). The annual mean total indirect cost for paid and unpaid work was AED 21,283 (USD 5795). Monthly income, nationality, and having two and more disease complications were the significant predictors of higher productivity loss costs. Having previously had a splenectomy was a negative and significant predictor of productivity loss costs.
TDT was associated with substantial productivity loss and indirect costs in the UAE. Health policies that aim to control transfusion-dependent thalassemia effectively are necessary and could result in cost savings for patients and employers.
本研究旨在评估阿拉伯联合酋长国迪拜输血依赖型地中海贫血（TDT）患者的间接负担。
成年TDT患者在输血期间入组。使用经过验证的iMTA生产力成本问卷（iPCQ）报告患者在前四周的生产力损失。
本研究共纳入161例成年TDT患者。79名就业患者在有偿工作中的年度总生产力损失成本为17230阿联酋迪拉姆（4691美元）（95%CI：12302-22159），其中旷工造成10328阿联酋迪拉姆（2812美元），出勤但生产力下降造成6902阿联酋迪拉姆（1879美元），而无偿工作的年度总生产力损失成本为4053阿联酋迪拉姆（1104美元）（95%CI：3471-4661）。有偿和无偿工作的年度平均总间接成本为21283阿联酋迪拉姆（5795美元）。月收入、国籍以及患有两种及以上疾病并发症是生产力损失成本较高的显著预测因素。既往行脾切除术是生产力损失成本的负性显著预测因素。
在阿联酋，TDT与大量生产力损失和间接成本相关。旨在有效控制输血依赖型地中海贫血的卫生政策是必要的，可为患者和雇主节省成本。
