A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease.

Exosomes are nano-sized extracellular vesicles that perform a variety of biological functions linked to the pathogenesis of various neurodegenerative disorders. In Alzheimer's disease (AD), for examples, exosomes are responsible for the release of oligomers, and their extracellular accumulation, although the underpinning molecular machinery remains elusive. We propose a novel model for Alzheimer's accumulation based on -dependent exosome release from astrocytes. Moreover, we exploit our model to assess how temperature dependence of exosome release could interact with neurotoxicity. We predict that voltage-gated channels (VGCCs) along with the transient-receptor potential M8 (TRPM8) channel are crucial molecular components in Alzheimer's progression.