Griffin Hailee, Pearson Scott, Linnebur Sunny, Fixen Danielle
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
SAGE Open Med Case Rep. 2021 Sep 30;9:2050313X211050465. doi: 10.1177/2050313X211050465. eCollection 2021.
Angioedema is a serious adverse event that can manifest as lower extremity edema, face swelling, rash, hives, and a swollen tongue, which can sometimes lead to airway constriction and death. It is a well-documented reaction within the angiotensin-converting enzyme inhibitor drug class, where the bradykinin pathway leads to angioedema. We report a case where a patient experienced angioedema after taking venlafaxine. We evaluated other antidepressants as potential treatment options for the patient. We further examined potential cross-reactivity between antidepressants in order to find alternative medications for patients that experience serious adverse effects.
血管性水肿是一种严重的不良事件，可表现为下肢水肿、面部肿胀、皮疹、荨麻疹和舌头肿胀，有时可导致气道狭窄和死亡。这是血管紧张素转换酶抑制剂药物类别中一种有充分记录的反应，其中缓激肽途径会导致血管性水肿。我们报告了一例患者在服用文拉法辛后出现血管性水肿的病例。我们评估了其他抗抑郁药作为该患者的潜在治疗选择。我们进一步研究了抗抑郁药之间潜在的交叉反应性，以便为出现严重不良反应的患者找到替代药物。
