Bessone Fernando
Department of Gastroenterology and Hepatology, Hospital Provincial del Centenario, Facultad de Ciencias Médicas, University of Rosario School of Medicine, Rosario 2000, Santa Fe, Argentina.
World J Gastrointest Pharmacol Ther. 2021 Sep 5;12(5):100-102. doi: 10.4292/wjgpt.v12.i5.100.
Drug-induced liver injury (DILI) is an uncommon event in clinical practice, which makes knowing its true incidence difficult. Prospective, retrospective and registry-based studies are the most important methods to obtain epidemiological data on DILI. Latin America (LA) has a historical lack of prospective studies on this topic. New definitions and the creation of hepatotoxicity registries have significantly improved the epidemiological understanding of hepatic drug reactions in several regions of the world. The Latin American DILI network, referred to as LATINDILI, has been created in 2011, and recently published its own DILI recommendations describing the most relevant issues on the management of hepatotoxicity in general, and those based on findings from our own LA experience in particular. Although most of the registries do not carry out population-based studies, they may provide important data related to the prevalence of DILI. The joint work among researchers and the corresponding health and regulatory authorities should be stimulated due to the high impact that hepatotoxicity represents for public health.
药物性肝损伤（DILI）在临床实践中并不常见，这使得了解其真实发病率变得困难。前瞻性、回顾性和基于登记处的研究是获取DILI流行病学数据的最重要方法。拉丁美洲（LA）历来缺乏关于该主题的前瞻性研究。新的定义和肝毒性登记处的设立显著提高了世界上几个地区对肝脏药物反应的流行病学认识。拉丁美洲DILI网络，即LATINDILI，于2011年成立，最近发布了自己的DILI建议，描述了一般肝毒性管理中最相关的问题，特别是基于我们拉丁美洲自身经验的发现。尽管大多数登记处没有开展基于人群的研究，但它们可能提供与DILI患病率相关的重要数据。由于肝毒性对公共卫生具有重大影响，应鼓励研究人员与相应的卫生和监管当局开展联合工作。
