是的，妈妈！
Yes, MAM!
作者信息
Means Robert E, Katz Samuel G
机构信息
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Mol Cell Oncol. 2021 May 19;8(4):1919473. doi: 10.1080/23723556.2021.1919473. eCollection 2021.
Abstract
Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria-associated membranes (MAMs) or mitochondria-ER contact sites (MERCs). We recently reported that BOK is present within MAMs where it regulates Ca transfer from the ER to the mitochondria, appropriate MAM components and MERC structure, and apoptosis.
摘要
BCL-2蛋白家族成员对细胞生死的调控发生在线粒体。线粒体的大部分外膜与内质网（ER）紧密相邻，即线粒体相关膜（MAMs）或线粒体-内质网接触位点（MERCs）。我们最近报道，BOK存在于MAMs中，在那里它调节钙从内质网到线粒体的转移、合适的MAM成分和MERC结构以及细胞凋亡。
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本文引用的文献
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Bok regulates mitochondrial fusion and morphology.Bok 调节线粒体融合和形态。
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