Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Chem Commun (Camb). 2021 Oct 21;57(84):11092-11095. doi: 10.1039/d1cc04576h.
Tandem reactions of the yttrium() catalyzed ring-opening reaction of 2,2'-diester aziridines with 3-(2-isocyanoethyl)indoles and the subsequent Friedel-Crafts/Mannich/desulfonylation were reported. A series of polycyclic spiroindolines containing tetrahydro-β-carbolines were obtained in moderate to excellent yields (56-92%) in one step under mild reaction conditions. A possible catalytic mechanism was also proposed.
报道了钇（Ⅲ）催化 2,2'-二酯基氮丙啶与 3-(2-异氰基乙基)吲哚的开环反应的串联反应，以及随后的傅克反应/曼尼希反应/脱磺化反应。在温和的反应条件下，一步法以中等至优异的收率（56-92%）得到了一系列含有四氢-β-咔啉的多环螺吲哚啉。还提出了一种可能的催化机理。
