Cano-López I, Vázquez-Costa J F, Gutiérrez A, Villanueva V, González-Bono E
Universidad Internacional de Valencia, Valencia, España.
Hospital Universitario y Politécnico La Fe, Valencia, España.
Rev Neurol. 2021 Oct 16;73(8):267-274. doi: 10.33588/rn.7308.2021109.
Temporal lobe epilepsy (TLE) surgery is an effective procedure that produces cognitive changes. Factors modulating such changes have been proposed, but the influence of cognitive reserve remains unclear.
To examine the effect of intellectual quotient (IQ) on postsurgical changes in verbal fluency, naming, and verbal and visual memory in a sample of patients with TLE.
64 adult patients with drug-resistant TLE (mean age ± SD: 39.16 ± 11.67) underwent a neuropsychological evaluation before and one year after surgery.
Patients with high IQ showed better immediate visual memory before surgery than those with medium IQ, as well as an absence of postsurgical changes. Patients with high manipulative IQ had better naming before surgery than those with medium manipulative IQ, as well as a significant postsurgical worsening. Both before and after surgery, patients with high IQ showed better phonemic and semantic verbal fluency and short- and long-term verbal memory than those with medium IQ.
IQ is a relevant factor in the evolution of immediate visual memory and naming after surgery in patients with TLE. Surgery does not impact on the advantage of high IQ patients in verbal fluency and verbal memory, suggesting that cognitive reserve has a positive effect on cognitive function, even after TLE surgery.
颞叶癫痫（TLE）手术是一种会引起认知变化的有效治疗方法。虽然已经提出了调节这些变化的因素，但认知储备的影响仍不明确。
在一组TLE患者样本中，研究智商（IQ）对术后言语流畅性、命名以及言语和视觉记忆变化的影响。
64例成年耐药性TLE患者（平均年龄±标准差：39.16±11.67）在手术前及术后一年接受了神经心理学评估。
高智商患者术前即时视觉记忆比中等智商患者更好，且术后无变化。高操作智商患者术前命名比中等操作智商患者更好，但术后显著恶化。术前和术后，高智商患者的音素和语义言语流畅性以及短期和长期言语记忆均优于中等智商患者。
IQ是TLE患者术后即时视觉记忆和命名演变的一个相关因素。手术不会影响高智商患者在言语流畅性和言语记忆方面的优势，这表明即使在TLE手术后，认知储备对认知功能也有积极影响。
