Int J Clin Pharmacol Ther. 2021 Dec;59(12):784-786. doi: 10.5414/CP204067.
A 35-year-old man with generalized insults was admitted to the intensive care unit because of third-line treatment of persistent epileptic insults with antiepileptic drug therapy. Topiramate was added on top of his outpatient regimen in combination with intravenous antiepileptic drugs. Miscommunication and inappropriate topiramate dosing (2,500 mg twice) resulted in an acute topiramate intoxication. Toxicokinetic assessment showed toxic serum topiramate concentration of 55 mg/L and a dose-dependent shift of peak time t. According to our modulations, t follows Y = 0.0009X + 2.65, where X is the topiramate dose. Our results have important implications for effectiveness of gut decontamination modalities.
一位 35 岁男性因癫痫持续发作，在接受三线抗癫痫药物治疗后出现全面性发作，被收入重症监护病房。在他的门诊治疗方案中添加了托吡酯，并结合静脉用抗癫痫药物进行治疗。沟通不畅和托吡酯剂量不当（2500mg，每日两次）导致急性托吡酯中毒。毒代动力学评估显示托吡酯血清中毒浓度为 55mg/L，峰时间 t 呈剂量依赖性变化。根据我们的调制，t 遵循 Y = 0.0009X + 2.65，其中 X 是托吡酯的剂量。我们的结果对肠道去污方式的有效性具有重要意义。
