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复方制剂基础:非无菌制剂中使用的辅料,第 11 部分:药物口感:先天的、诱导的和改善的。

Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved.

机构信息

International Journal of Pharmaceutical Compounding.

出版信息

Int J Pharm Compd. 2021 Sep-Oct;25(5):396-400.

Abstract

Many drugs inherently have a taste associated with them when in solution; these are the innate or inherent tastes associated with the drug itself and are often included in the official United States Pharmacopeia-National Formulary description of the drug. Some drugs will induce a taste or a change in taste characteristics when administered to a patient; these are induced tastes and a long list of examples is included in this article. Oftentimes, it is necessary to alter the properties of a dosage form to overcome disagreeable tastes of drugs through the use of different flavoring methods, which is also discussed. Patient compliance is critical for effective therapy and taste is important for compliance.

摘要

许多药物在溶液中本身就具有一种与之相关的味道;这些是与药物本身相关的内在或固有味道,通常包含在药物的官方美国药典-国家配方描述中。一些药物在给患者使用时会引起味觉或味觉特征的变化;这些是诱导性味道,本文中包含了一长串例子。通常,有必要通过使用不同的调味方法来改变剂型的性质,以克服药物令人不快的味道,这也将进行讨论。患者的依从性对于有效的治疗至关重要,而味道对于依从性很重要。

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