School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Aspect Biosystems, Vancouver, BC V6P 6P2, Canada.
School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Cell Stem Cell. 2021 Oct 7;28(10):1690-1707. doi: 10.1016/j.stem.2021.09.001.
Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and regeneration of most tissues. They can differentiate along multiple connective lineages, but unlike most other stem/progenitor cells, they carry out various other functions while maintaining their developmental potential. MSCs function as damage sensors, respond to injury by fostering regeneration through secretion of trophic factors as well as extracellular matrix (ECM) molecules, and contribute to fibrotic reparative processes when regeneration fails. Tissue-specific MSC identity, fate(s), and function(s) are being resolved through fate mapping coupled with single cell "omics," providing unparalleled insights into the secret lives of tissue-resident MSCs.
多能基质细胞（MSCs）对于大多数组织的发育、维持、功能和再生至关重要。它们可以沿着多种结缔组织谱系分化，但与大多数其他干细胞/祖细胞不同，它们在保持其发育潜能的同时还执行各种其他功能。MSCs 作为损伤传感器，通过分泌营养因子和细胞外基质（ECM）分子促进再生来响应损伤，并在再生失败时促进纤维化修复过程。通过与单细胞“组学”相结合的命运图谱，正在解析组织特异性 MSC 的身份、命运和功能，为组织驻留 MSC 的秘密生活提供了无与伦比的见解。
