Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3016-3023. doi: 10.1016/j.numecd.2021.07.031. Epub 2021 Aug 5.
Meta-analysis was performed to assess the value of serum uric acid in the prognosis of ischemic stroke.
We searched the databases of PubMed, Embase, and Web of Science. The literature we searched was published from the establishment of the database to January 2021. The references of the included literature were also collected. Two researchers sifted through the literature according to the inclusion and exclusion criteria and extracted the data. Stata 16.0 software was used for meta-analysis, and funnel plots were used to evaluate publication bias. Ten studies fulfilled the research criteria and were eventually included, and the analysis results showed that there was no significant association between serum uric acid and the functional outcome (OR = 0.99, 95% CI; 0.97-1.10), poor outcome (OR = 1.07, 95% CI; 0.99-1.15), vascular events (OR = 0.86, 95% CI; 0.52-1.41), and mortality (OR = 1.08, 95% CI; 0.93-1.24) related to ischemic stroke.
There was no significant correlation between serum uric acid level and prognosis of ischemic stroke.
通过荟萃分析评估血清尿酸在缺血性脑卒中预后评估中的价值。
我们检索了 PubMed、Embase 和 Web of Science 数据库。我们检索的文献发表时间从数据库建立到 2021 年 1 月。还收集了纳入文献的参考文献。两位研究者根据纳入和排除标准筛选文献并提取数据。使用 Stata 16.0 软件进行荟萃分析，并使用漏斗图评估发表偏倚。有 10 项研究符合研究标准，最终被纳入分析，结果表明血清尿酸与功能结局（OR=0.99，95%CI：0.97-1.10）、不良结局（OR=1.07，95%CI：0.99-1.15）、血管事件（OR=0.86，95%CI：0.52-1.41）和缺血性脑卒中相关的死亡率（OR=1.08，95%CI：0.93-1.24）之间无显著相关性。
血清尿酸水平与缺血性脑卒中的预后之间无显著相关性。
