Cai Hua-Ying, Fu Xiao-Xiao, Jiang Hong, Han Shu
Department of Neurology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.
Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
NPJ Parkinsons Dis. 2021 Oct 8;7(1):91. doi: 10.1038/s41531-021-00233-3.
Animal studies have indicated that increased blood-brain barrier (BBB) permeability and inflammatory cell infiltration are involved during the progression of Parkinson's disease (PD). This study used C16, a peptide that competitively binds to integrin αβ and inhibits inflammatory cell infiltration, as well as angiopoietin-1 (Ang-1), an endothelial growth factor crucial for blood vessel protection, to reduce inflammation and improve the central nervous system (CNS) microenvironment in murine models of PD. The combination of C16 and Ang-1 yielded better results compared to the individual drugs alone in terms of reducing dopaminergic neuronal apoptosis, ameliorating cognitive impairment, and electrophysiological dysfunction, attenuating inflammation in the CNS microenvironment, and improving the functional disability in PD mice or rats. These results suggest neuroprotective and anti-inflammatory properties of the C16 peptide plus Ang-1 in PD.
动物研究表明，血脑屏障（BBB）通透性增加和炎性细胞浸润参与帕金森病（PD）的进展过程。本研究使用C16（一种能与整合素αβ竞争性结合并抑制炎性细胞浸润的肽）以及血管生成素-1（Ang-1，一种对血管保护至关重要的内皮生长因子），以减轻炎症并改善PD小鼠模型的中枢神经系统（CNS）微环境。与单独使用单一药物相比，C16和Ang-1联合使用在减少多巴胺能神经元凋亡、改善认知障碍和电生理功能障碍、减轻CNS微环境中的炎症以及改善PD小鼠或大鼠的功能残疾方面产生了更好的效果。这些结果表明C16肽加Ang-1在PD中具有神经保护和抗炎特性。
