Department of Psychiatry, Hebei Province Veterans Hospital, Baoding, People's Republic of China.
Lian Yang Community Health Service Center, Shanghai, People's Republic of China.
Sci Rep. 2021 Oct 8;11(1):20057. doi: 10.1038/s41598-021-99510-7.
Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naïve first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients.
脑源性神经营养因子（BDNF）被报道与精神分裂症（SZ）患者的认知能力下降有关。先前的研究发现，SZ 患者在慢性疾病阶段认知缺陷保持稳定，但结果不一致。BDNF 在疾病不同阶段认知缺陷中的作用尚不清楚。本研究旨在探讨 BDNF 多态性对药物初发（DNFE）和慢性 SZ 患者认知缺陷的影响。共招募了 262 名 DNFE 患者、844 名慢性患者和 1043 名健康对照者，比较了 BDNF 基因的 4 种多态性与认知功能。我们发现，SZ 患者与对照组在基因型和等位基因频率上无显著差异。然而，它们与认知功能密切相关。BDNF rs2030324 多态性仅在 DNFE 患者中对语言表现起重要作用。rs2030324 TT 和 TC 基因型的 DNFE 患者的语言指数比慢性患者差，但 CC 基因型在 DNFE 和慢性患者之间无显著差异。rs6265 对患者和对照组的认知功能无显著影响。我们的结果表明，BDNF 基因多态性与 SZ 不同阶段不同认知功能域有关，特别是 DNFE 患者的语言功能。
