Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Department of Obstetrics and Gynecology, Faculty of Li Kai Shing Medicine, University of Hong Kong, Hong Kong, China.
Bull Exp Biol Med. 2021 Sep;171(5):644-650. doi: 10.1007/s10517-021-05286-1. Epub 2021 Oct 9.
Recent studies showed that gut microbiota can be implicated in the control over glucose metabolism in the host organism. This study employed the Lin28a transgenic mice (Lin28a Tg) characterized by low fasting glucose levels and improved glucose tolerance test in comparison with the wild type species. 16S rDNA gene sequencing showed that the transgenic mice were distinguished by altered species richness of microbiota. Specifically, Lin28a Tg mice displayed higher abundance of Proteobacteria, Bacteroides, Parabacteroides, and lower abundance of Firmicutes known to be closely implicated in glucose metabolism. These data suggest that the peculiar profile of gut microbiota in Lin28a Tg mice can be directly involved in the control of glucose metabolism in the host organism.
最近的研究表明，肠道微生物群可以参与宿主生物体内葡萄糖代谢的控制。本研究采用 Lin28a 转基因小鼠（Lin28aTg）作为研究对象，与野生型相比，Lin28aTg 小鼠的空腹血糖水平较低，葡萄糖耐量试验改善。16S rDNA 基因测序显示，转基因小鼠的微生物群物种丰富度发生了改变。具体而言，Lin28aTg 小鼠表现出更多的变形菌门、拟杆菌门、副拟杆菌门，而厚壁菌门的丰度较低，而厚壁菌门与葡萄糖代谢密切相关。这些数据表明，Lin28aTg 小鼠肠道微生物群的特殊特征可能直接参与宿主生物体内葡萄糖代谢的控制。
