Ye Qin, Chen Shu-Han, Zhang Ya, Ruan Bo, Zhang Yi-Jie, Zhang Xin-Ke, Jiang Tao, Wang Xiaoge, Ma Ning, Tsai Fang-Chang
Hubei Key Laboratory of Polymer Materials, Key Laboratory for the Green Preparation and Application of Functional Materials (Ministry of Education), Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, School of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Department Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Macromol Biosci. 2021 Dec;21(12):e2100317. doi: 10.1002/mabi.202100317. Epub 2021 Oct 19.
The mechanical properties of artificial skins are complicated to maintain under ensuring air permeability and antimicrobial. Thus, a series of hydrophilic antimicrobial polymer networks are prepared by crosslinking chitosan and polyvinyl alcohol with the lauramidopropyl betaine and hydrogen bond organic framework (CS/PVA/LPB/2D-HOF). The mechanical performance of the control groups and the complex are systematically evaluated to attain an artificial strength skin. The CS/PVA/LPB/2D-HOF complex exhibits strong mechanical abilities than other control groups. By analyzing the IR spectra and the morphology, the synergistic effect of hydrogen bonds between molecules and cracks significantly improves the mechanical properties of the complex. Its maximum tensile strength can reach 29 MPa, and its maximum load capacity can reach 3700 g. Notably, the composite membrane also performs an excellent antimicrobial activity. In vivo and in vitro experiments show that the hybrid membrane can promote tissue regeneration and wound healing (95％). These results may open up the opportunity for future composite material investigations in the artificial skin and tissue engineering field.
在确保透气性和抗菌性的情况下，维持人造皮肤的机械性能很复杂。因此，通过壳聚糖和聚乙烯醇与月桂酰胺丙基甜菜碱和氢键有机骨架交联制备了一系列亲水性抗菌聚合物网络（CS/PVA/LPB/2D-HOF）。系统评估对照组和复合物的机械性能以获得具有人工强度的皮肤。CS/PVA/LPB/2D-HOF复合物表现出比其他对照组更强的机械性能。通过分析红外光谱和形态，分子间氢键和裂纹的协同作用显著提高了复合物的机械性能。其最大拉伸强度可达29MPa，最大负载能力可达3700g。值得注意的是，复合膜还具有优异的抗菌活性。体内和体外实验表明，混合膜可促进组织再生和伤口愈合（95％）。这些结果可能为未来在人造皮肤和组织工程领域的复合材料研究开辟机会。
