性别匹配对 Fuchs 内皮角膜营养不良行 DSAEK 后 2 年排斥或失败率无影响。
Gender Matching Did Not Affect 2-year Rejection or Failure Rates Following DSAEK for Fuchs Endothelial Corneal Dystrophy.
机构信息
From the Royal Liverpool University Hospital, Liverpool, UK (V.R, G.C, K.I, S.B.K); Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK (V.R, S.B.K).
UCL Institute of Ophthalmology, London, UK (M.P).
出版信息
Am J Ophthalmol. 2022 Mar;235:204-210. doi: 10.1016/j.ajo.2021.09.029. Epub 2021 Oct 6.
PURPOSE
To investigate whether donor to recipient gender or H-Y mismatching was associated with graft rejection or failure following Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with Fuchs endothelial corneal dystrophy (FECD).
DESIGN
Clinical cohort study.
METHODS
This study used a multi-center registry including patients aged >18 years who had undergone their first DSAEK for FECD between January 2008 and March 2018. The impact of donor and recipient gender incompatibility (including H-Y mismatches) on corneal graft rejection and failure was evaluated using Kaplan-Meier curves and univariable and multivariable Cox models.
RESULTS
Outcome data from 4341 eyes (3915 from the UK and 426 from Italy) were analyzed. Graft failure at 2-year follow-up occurred in 477 (11.0%) cases. Graft rejection at 2-year follow-up occurred in 175 cases (4.0%), 58 (1.3%) of whom developed graft failure. There was no significant effect of gender or H-Y mismatching on either rejection (P = .12, P = .06) or failure (P = .28, P = .14), respectively.
CONCLUSIONS
In patients with FECD undergoing DSAEK, no significant influence of gender and or H-Y mismatch on graft rejection or failure was found.
目的
研究在接受富克斯角膜内皮营养不良（FECD）的患者中，供体与受体性别或 H-Y 不匹配是否与 Descemet 撕囊自动角膜内皮移植术（DSAEK）后的移植物排斥或失败有关。
设计
临床队列研究。
方法
本研究使用了一个多中心登记处，包括 2008 年 1 月至 2018 年 3 月期间首次接受 DSAEK 治疗 FECD 的年龄大于 18 岁的患者。使用 Kaplan-Meier 曲线和单变量及多变量 Cox 模型评估供体和受体性别不匹配（包括 H-Y 不匹配）对角膜移植物排斥和失败的影响。
结果
对来自英国的 3915 只眼和意大利的 426 只眼的 4341 只眼的结果数据进行了分析。在 2 年随访时发生移植物失败的有 477 例（11.0%）。在 2 年随访时发生移植物排斥的有 175 例（4.0%），其中 58 例（1.3%）发生移植物失败。性别或 H-Y 不匹配对排斥（P=0.12，P=0.06）或失败（P=0.28，P=0.14）均无显著影响。
结论
在接受 DSAEK 治疗的 FECD 患者中，未发现性别和或 H-Y 不匹配对移植物排斥或失败有显著影响。
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