Universidade Federal de S.·o Paulo, Centro de Estudo, Diagn..stico e Investiga...·o de Hipertermia Maligna (CEDHIMA), Disciplina de Anestesiologia, Dor e Terapia Intensiva, S.·o Paulo, SP, Brazil.
Universidade Federal de S.·o Paulo, Centro de Estudo, Diagn..stico e Investiga...·o de Hipertermia Maligna (CEDHIMA), Disciplina de Anestesiologia, Dor e Terapia Intensiva, S.·o Paulo, SP, Brazil.
Braz J Anesthesiol. 2023 Mar-Apr;73(2):132-137. doi: 10.1016/j.bjane.2021.07.038. Epub 2021 Oct 6.
Malignant Hyperthermia (MH) is a pharmacogenetic disorder triggered by halogenated anesthesia agents/succinylcholine and characterized by hypermetabolism crisis during anesthesia, but also by day-to-day symptoms, such as exercise intolerance, that may alert the health professional.
The study aimed to analyze the incidence of fatigue in MH susceptible patients and the variables that can impact perception of fatigue, such as the level of routine physical activity and depression.
A cross-sectional observational study was carried out with three groups ... 22 patients susceptible to MH (positive in vitro muscle contracture test), 13 non-susceptible to MH (negative in vitro muscle contracture test) and 22 controls (no history of MH). Groups were assessed by a demographic/clinical questionnaire, a fatigue severity scale (intensity, specific situations, psychological consequences, rest/sleep response), and the Beck depression scale. Subgroups were re-assessed with the Baecke habitual physical exercise questionnaire (occupational physical activity, leisure physical exercise, leisure/locomotion physical activity).
There were no significant differences among the three groups regarding fatigue intensity, fatigue related to specific situations, psychological consequences of fatigue, fatigue response to resting/sleeping, depression, number of active/sedentary participants, and the mean time and characteristics of habitual physical activity. Nevertheless, unlike the control sub-group, the physically active MH-susceptible subgroup had a higher fatigue response to resting/sleeping than the sedentary MH susceptible subgroup (respectively, 5.9.ß...ß1.9 vs. 3.9.ß...ß2, t-test unpaired, p.ß<.ß0.05).
We did not detect subjective fatigue in MH susceptible patients, although we reported protracted recovery after physical activity, which may alert us to further investigation requirements.
恶性高热（MH）是一种由卤代麻醉剂/琥珀酰胆碱触发的遗传药理学疾病，其特征是麻醉期间发生代谢危机，但也存在日常症状，如运动不耐受，这可能会引起健康专业人员的注意。
本研究旨在分析易患 MH 的患者疲劳的发生率，以及可能影响疲劳感知的变量，如常规体力活动水平和抑郁。
进行了一项横断面观察性研究，涉及三组患者……22 例易患 MH（体外肌肉挛缩试验阳性）、13 例不易患 MH（体外肌肉挛缩试验阴性）和 22 例对照（无 MH 病史）。通过人口统计学/临床问卷、疲劳严重程度量表（强度、特定情况、心理后果、休息/睡眠反应）和贝克抑郁量表对各组进行评估。使用 Baecke 习惯性体力活动问卷（职业体力活动、休闲体力活动、休闲/运动体力活动）对亚组进行重新评估。
三组之间的疲劳强度、与特定情况相关的疲劳、疲劳对休息/睡眠的反应、抑郁、活跃/久坐参与者的数量、习惯性体力活动的平均时间和特征均无显著差异。然而，与对照组不同，活跃的易患 MH 亚组比久坐的易患 MH 亚组对休息/睡眠的疲劳反应更高（分别为 5.9.ß...ß1.9 比 3.9.ß...ß2，配对 t 检验，p.ß<.ß0.05）。
我们并未在易患 MH 的患者中检测到主观疲劳，但我们报告了体力活动后恢复时间延长，这可能会引起我们对进一步调查的需求。
