Cancer Biology Lab, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh 530045, India; Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh 530045, India.
Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be) University, Visakhapatnam, Andhra Pradesh 530045, India.
Phytomedicine. 2021 Dec;93:153782. doi: 10.1016/j.phymed.2021.153782. Epub 2021 Sep 28.
Lung cancer is a significant health concern worldwide due to high mortality and morbidity, despite the advances in diagnosis, treatment, and management. Recent experimental evidence from different models suggested long non-coding RNAs (lncRNAs) as major modulators of cancer stem cells (CSCs) in the tumor microenvironment (TME) to support metastasis and drug resistance in lung cancer. Evidence-based studies demonstrated that natural products interfere with TME functions.
To establish lncRNAs of TME as novel targets of natural compounds for lung cancer management.
Current study used a combination of TME and lung CSCs, lncRNAs and enrichment and stemness maintenance, natural products and stem cell management, natural products and lncRNAs, natural products and targeted delivery as keywords to retrieve the literature from Scopus, Web of Science, PubMed, and Google Scholar. This study critically reviewed the current literature and presented cancer stem cells' ability in reprogramming lung TME.
This review found that TME related oncogenic and tumor suppressor lncRNAs and their signaling pathways control the maintenance of stemness in lung TME. This review explored natural phenolic compounds and found that curcumin, genistein, quercetin epigallocatechin gallate and ginsenoside Rh2 are efficient in managing lung CSCs. They modulate lncRNAs and their upstream mediators by targeting signaling and epigenetic pathways. This review also identified relevant nanotechnology-based phytochemical delivery approaches for targeting lung cancer.
By critical literature analysis, TME related lncRNAs were identified as potential therapeutic targets, aiming to develop natural product-based therapeutics to treat metastatic and drug-resistant lung cancers.
尽管在诊断、治疗和管理方面取得了进展，但肺癌仍是全球范围内一个严重的健康问题，其发病率和死亡率都很高。来自不同模型的最新实验证据表明，长链非编码 RNA（lncRNA）作为肿瘤微环境（TME）中癌症干细胞（CSC）的主要调节剂，可支持肺癌的转移和耐药性。基于证据的研究表明，天然产物可干扰 TME 功能。
将 TME 的 lncRNA 确立为天然化合物治疗肺癌的新靶点。
本研究采用 TME 和肺 CSC、lncRNA 和富集及干细胞维持、天然产物和干细胞管理、天然产物和 lncRNA、天然产物和靶向递送来作为关键词，从 Scopus、Web of Science、PubMed 和 Google Scholar 中检索文献。本研究对当前文献进行了批判性回顾，并提出了癌症干细胞在重塑肺 TME 方面的能力。
本综述发现，TME 相关的致癌和肿瘤抑制性 lncRNA 及其信号通路控制着肺 TME 中干细胞特性的维持。本综述探讨了天然酚类化合物，发现姜黄素、染料木黄酮、槲皮素、表没食子儿茶素没食子酸酯和人参皂苷 Rh2 可有效管理肺 CSC。它们通过靶向信号和表观遗传途径来调节 lncRNA 及其上游介质。本综述还确定了基于相关纳米技术的植物化学物质递药方法，用于靶向肺癌。
通过对文献的批判性分析，确定了与 TME 相关的 lncRNA 作为潜在的治疗靶点，旨在开发基于天然产物的疗法来治疗转移性和耐药性肺癌。
