Internal Medicine Department, Icahn School of Medicine at Mount Sinai / NYC Health+Hospitals / Queens, New York, NY, USA.
Clinical Oncology Department, Nottingham University Hospital, Nottingham, UK.
Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102274. doi: 10.1016/j.dsx.2021.102274. Epub 2021 Sep 8.
Adrenal Insufficiency (AI) is rarely observed in patients with cardiogenic shock (CS). We aimed to identify the prevalence of AI in patients with CS and its effect on their clinical outcomes.
Our study aimed to determine the prevalence of AI in CS patients who underwent treatments for CS.
The articles concerning AI in CS were extracted for review from PubMed/Medline, Science Direct, World Wide Science.org, and Pro-Quest. The research articles included patients with CS, post-cardiac-arrest shock, out-of-hospital cardiac arrest, and CS after acute myocardial infarction. RStudio (version 1.0.136) was used for analyzing AI in CS patients.
The search revealed 1463 unique publications, including 256 studies identified after screening the titles and the abstracts. Five observational cohort studies met the eligibility criteria for meta-analysis after the preliminary screening. The included studies reported a corticotropin stimulation test for AI diagnosis. The studies reportedly exhibited a low-to-fair quality. The random-effects pooled estimates indicated a 32% AI prevalence in the setting of CS [95% CI; 21%-45%; I = 81%]. The outcomes from the included studies were statistically significant for high heterogeneity (P = 0.001). The pooled results confirmed an 11%-51% AI prevalence in CS patients.
This meta-analysis revealed a moderate level prevalence of AI in CS patients.
在心源休克（CS）患者中很少观察到肾上腺功能不全（AI）。我们旨在确定 CS 患者中 AI 的患病率及其对其临床结局的影响。
我们的研究旨在确定接受 CS 治疗的 CS 患者中 AI 的患病率。
从 PubMed/Medline、Science Direct、World Wide Science.org 和 Pro-Quest 中提取有关 CS 中 AI 的文章进行综述。研究文章包括 CS 患者、心脏骤停后休克、院外心脏骤停和急性心肌梗死后 CS。使用 RStudio（版本 1.0.136）分析 CS 患者中的 AI。
搜索结果显示有 1463 篇独特的出版物，包括经过标题和摘要筛选后确定的 256 项研究。经过初步筛选后，有 5 项观察性队列研究符合荟萃分析的纳入标准。纳入的研究报告了 AI 诊断的促皮质素刺激试验。研究报告显示质量为低到中等。随机效应汇总估计表明 CS 中 AI 的患病率为 32%[95%CI；21%-45%；I = 81%]。纳入研究的结果在统计学上具有显著的高度异质性（P = 0.001）。汇总结果证实 CS 患者中 AI 的患病率为 11%-51%。
这项荟萃分析显示 CS 患者中 AI 的患病率处于中等水平。
