Sadrabadi Mohammadreza Soltany, Eskandari Mona, Feigenbaum Heidi P, Arzani Amirhossein
Department of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, USA.
Department of Mechanical Engineering, University of California Riverside, Riverside, CA, USA; BREATHE Center at the School of Medicine, University of California Riverside, Riverside, CA, USA; Department of Bioengineering, University of California Riverside, Riverside, CA, USA.
J Biomech. 2021 Nov 9;128:110773. doi: 10.1016/j.jbiomech.2021.110773. Epub 2021 Sep 30.
Aging and calcific aortic valve disease (CAVD) are the main factors leading to aortic stenosis. Both processes are accompanied by growth and remodeling pathways that play a crucial role in aortic valve pathophysiology. Herein, a computational growth and remodeling (G&R) framework was developed to investigate the effects of aging and calcification on aortic valve dynamics. Particularly, an algorithm was developed to couple the global growth and stiffening of the aortic valve due to aging and the local growth and stiffening due to calcification with the aortic valve transient dynamics. The aortic valve dynamics during baseline were validated with available data in the literature. Subsequently, the changes in aortic valve dynamic patterns during aging and CAVD progression were studied. The results revealed the patterns in geometric orifice area reduction and an increase in the valve stress during local and global growth and remodeling of the aortic valve. The proposed algorithm provides a framework to couple mechanobiology models of disease growth with tissue-scale transient structural mechanics models to study the biomechanical changes during cardiovascular disease growth and aging.
衰老和钙化性主动脉瓣疾病（CAVD）是导致主动脉瓣狭窄的主要因素。这两个过程都伴随着生长和重塑途径，这些途径在主动脉瓣病理生理学中起着至关重要的作用。在此，开发了一种计算生长和重塑（G&R）框架，以研究衰老和钙化对主动脉瓣动力学的影响。特别是，开发了一种算法，将由于衰老导致的主动脉瓣整体生长和硬化以及由于钙化导致的局部生长和硬化与主动脉瓣瞬态动力学耦合起来。利用文献中的现有数据对基线期间的主动脉瓣动力学进行了验证。随后，研究了衰老和CAVD进展过程中主动脉瓣动态模式的变化。结果揭示了在主动脉瓣局部和整体生长及重塑过程中几何开口面积减小和瓣膜应力增加的模式。所提出的算法提供了一个框架，将疾病生长的力学生物学模型与组织尺度的瞬态结构力学模型耦合起来，以研究心血管疾病生长和衰老过程中的生物力学变化。
