Department of Urology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute City, Aichi 480-1195, Japan.
J Smooth Muscle Res. 2021;57(0):49-52. doi: 10.1540/jsmr.57.49.
There are various refractory chronic inflammatory diseases related to the genitourinary tract, such as interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome. It has been reported that in the general population, these diseases are related to other chronic illnesses, such as irritable bowel syndrome or vulvodynia. Herein, we review papers regarding pelvic organ cross-sensitization, a factor which is considered to contribute to these relationships. Several other researchers and ourselves have reported that noxious stimuli from a diseased pelvic organ are transmitted to an adjacent normal structure via shared sensory neural pathways at the prespinal, spinal, and supraspinal levels, resulting in functional changes in the adjacent normal structure. In conclusion, since there are few treatments to cure interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome completely, further studies regarding organ cross-sensitization may provide new insights into the pathophysiology and treatment strategies for these diseases.
有许多与泌尿生殖道相关的难治性慢性炎症性疾病，如间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性骨盆疼痛综合征。据报道，在普通人群中，这些疾病与其他慢性疾病有关，如肠易激综合征或外阴痛。在此，我们回顾了有关盆腔器官交叉敏感的文献，这一因素被认为是导致这些疾病的原因之一。其他几位研究人员和我们自己已经报告说，来自患病盆腔器官的有害刺激通过脊髓前、脊髓和脊髓以上水平的共享感觉神经通路传递到相邻的正常结构，导致相邻正常结构的功能发生变化。总之，由于目前尚无完全治愈间质性膀胱炎/膀胱疼痛综合征和慢性前列腺炎/慢性骨盆疼痛综合征的方法，因此，对器官交叉敏感的进一步研究可能为这些疾病的病理生理学和治疗策略提供新的见解。
