Commander Clayton W, Mauro David M
Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Semin Intervent Radiol. 2021 Oct;38(4):397-404. doi: 10.1055/s-0041-1735616. Epub 2021 Oct 7.
Transarterial radioembolization of primary and secondary hepatic malignancies utilizing yttrium-90 microspheres is a commonly performed treatment by interventional radiologists. Traditionally performed as a two-part procedure, a diagnostic angiography is performed 1 to 3 weeks prior to treatment with the injection of technetium-99m-macroaggregated albumin followed by planar scintigraphy in the nuclear medicine department. Careful attention must be paid to the details during the diagnostic angiography to ensure the delivery of a safe and optimal dose to the diseased liver and to minimize radiation-induced damage to both unaffected liver and adjacent structures. In this article, we will review the steps and considerations that must be made during the angiography planning and discuss current and future areas of research.
利用钇-90微球对原发性和继发性肝恶性肿瘤进行经动脉放射性栓塞是介入放射科医生常用的治疗方法。传统上,该治疗分两部分进行,即在治疗前1至3周进行诊断性血管造影,先注射锝-99m-大颗粒白蛋白,然后在核医学科进行平面闪烁扫描。在诊断性血管造影过程中必须注意细节,以确保向患病肝脏输送安全且最佳剂量的药物,并尽量减少对未受影响的肝脏和邻近结构的辐射损伤。在本文中,我们将回顾血管造影规划过程中必须采取的步骤和考虑因素,并讨论当前和未来的研究领域。