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Commentary: Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption.

作者信息

Beard Daniel J, Hadley Gina, Sutherland Brad A, Buchan Alastair M

机构信息

School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.

Laboratory of Cerebral Ischaemia, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

出版信息

Front Physiol. 2021 Sep 22;12:761556. doi: 10.3389/fphys.2021.761556. eCollection 2021.

DOI:10.3389/fphys.2021.761556
PMID:34630168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8493210/
Abstract
摘要

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1
Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption.Rapalink-1在早期脑缺血再灌注中增加梗死面积并加剧血脑屏障破坏。
Front Physiol. 2021 Jul 20;12:706528. doi: 10.3389/fphys.2021.706528. eCollection 2021.
2
Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia.新型 mTOR 抑制剂 AZD2014 在神经元缺血中的研究。
Neurosci Lett. 2019 Jul 27;706:223-230. doi: 10.1016/j.neulet.2019.05.023. Epub 2019 May 14.
3
Inhibition of p70 ribosomal S6 kinase 1 (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability.p70 核糖体 S6 激酶 1（S6K1）的抑制作用（由 PF-4708671 实现）降低了脑缺血再灌注早期的梗死面积，并降低了 BBB 通透性。
Eur J Pharmacol. 2019 Jul 15;855:202-207. doi: 10.1016/j.ejphar.2019.05.010. Epub 2019 May 4.
4
The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.雷帕霉素治疗对脑缺血的影响：动物模型研究的系统评价和荟萃分析。
Int J Stroke. 2019 Feb;14(2):137-145. doi: 10.1177/1747493018816503. Epub 2018 Nov 29.
5
Rapamycin in ischemic stroke: Old drug, new tricks?雷帕霉素治疗缺血性脑卒中：老药新用？
J Cereb Blood Flow Metab. 2019 Jan;39(1):20-35. doi: 10.1177/0271678X18807309. Epub 2018 Oct 18.
6
Activation of Akt by SC79 decreased cerebral infarct in early cerebral ischemia-reperfusion despite increased BBB disruption.尽管血脑屏障破坏增加，但SC79激活Akt可减少早期脑缺血再灌注中的脑梗死。
Neurosci Lett. 2018 Aug 10;681:78-82. doi: 10.1016/j.neulet.2018.05.046. Epub 2018 May 30.
7
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.一种靶向mTORC1的激酶抑制剂可促使胶质母细胞瘤消退。
Cancer Cell. 2017 Mar 13;31(3):424-435. doi: 10.1016/j.ccell.2017.01.014.
8
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.用新一代mTOR抑制剂克服mTOR抗性突变。
Nature. 2016 Jun 9;534(7606):272-6. doi: 10.1038/nature17963. Epub 2016 May 18.
9
Effects of rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion.雷帕霉素预处理对脑缺血再灌注中血脑屏障破坏的影响。
Neurosci Lett. 2016 May 4;620:132-6. doi: 10.1016/j.neulet.2016.03.053. Epub 2016 Mar 30.
10
Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia.雷帕霉素对脑缺血再灌注期间脑氧供应和消耗的影响。
Neuroscience. 2016 Mar 1;316:321-7. doi: 10.1016/j.neuroscience.2015.12.045. Epub 2015 Dec 29.