Pattan Vishwanath, Kashyap Rahul, Bansal Vikas, Candula Narsimha, Koritala Thoyaja, Surani Salim
Division of Endocrinology, Wyoming Medical Center, Casper, WY 82601, United States.
Department of Anesthesiology and Peri-operative Medicine, Mayo Clinic, Rochester, MN 55905, United States.
World J Methodol. 2021 Sep 20;11(5):231-242. doi: 10.5662/wjm.v11.i5.231.
The sequencing of complete human genome revolutionized the genomic medicine. However, the complex interplay of gene-environment-lifestyle and influence of non-coding genomic regions on human health remain largely unexplored. Genomic medicine has great potential for diagnoses or disease prediction, disease prevention and, targeted treatment. However, many of the promising tools of genomic medicine are still in their infancy and their application may be limited because of the limited knowledge we have that precludes its use in many clinical settings. In this review article, we have reviewed the evolution of genomic methodologies/tools, their limitations, and scope, for current and future clinical application.
完整人类基因组的测序彻底改变了基因组医学。然而,基因-环境-生活方式之间复杂的相互作用以及非编码基因组区域对人类健康的影响在很大程度上仍未得到探索。基因组医学在疾病诊断或预测、疾病预防及靶向治疗方面具有巨大潜力。然而,许多有前景的基因组医学工具仍处于起步阶段,由于我们所掌握的知识有限,妨碍了其在许多临床环境中的应用,因此其应用可能受到限制。在这篇综述文章中,我们回顾了基因组方法/工具的发展历程、它们的局限性和应用范围,以及其当前和未来的临床应用情况。