泼尼松对缓解期白血病儿童红细胞生成的刺激作用。
Prednisone stimulation of erythropoiesis in leukemic children during remission.
作者信息
Amylon M D, Perrine S P, Glader B E
出版信息
Am J Hematol. 1986 Oct;23(2):179-81. doi: 10.1002/ajh.2830230213.
PMID:3463202
Abstract
Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 +/- 1.1 g/dl) following prednisone pulse therapy. This hemoglobin increment is not associated with changes in serum erythropoietin activity. It is speculated that this stimulation of red cell production may be a direct effect of steroids on erythroid progenitor cells.
摘要
缓解期的急性白血病患儿在接受泼尼松冲击治疗后会出现网织红细胞增多以及血红蛋白浓度显著升高（平均升高2.3±1.1 g/dl）。这种血红蛋白的升高与血清促红细胞生成素活性的变化无关。据推测，这种对红细胞生成的刺激可能是类固醇对红系祖细胞的直接作用。
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