Reid I R, Schooler B A, Hannan S F, Ibbertson H K
Aust N Z J Med. 1986 Apr;16(2):193-7. doi: 10.1111/j.1445-5994.1986.tb01147.x.
Changes in serum and urine biochemical indices have been studied in ten normal subjects in the four hours following the ingestion of four proprietary calcium supplements. Each was taken in a dose containing 1 gram of elemental calcium. The four preparations were ranked according to the amount of calcium absorbed in the order Spar-Cal and Calcium Sandoz greater than Os-Cal greater than Ossopan. There were no significant differences between the four preparations in the changes in parathyroid hormone (PTH) and urine hydroxyproline levels. For this reason, the four results from each subject were averaged. Following the calcium load there was a reduction in mean PTH from 0.16 +/- 0.01 to 0.10 +/- 0.02 micrograms/l (p less than 0.001) and a decline in urine hydroxyproline/creatinine ratio from 20 +/- 1 to 17 +/- 1 (p less than 0.02), suggesting that bone resorption responds immediately to dietary calcium intake. There was a rise in urine sodium excretion which correlated with the indices of calcium absorption (r = 0.63, p less than 0.01) but not with the sodium content of the calcium preparations. This effect could be important, particularly in elderly patients on borderline sodium intakes.
对10名正常受试者在摄入4种专利钙补充剂后的4小时内血清和尿液生化指标的变化进行了研究。每种补充剂的服用剂量均含1克元素钙。这4种制剂按钙吸收量排序为：斯帕卡尔（Spar-Cal）和山德士钙（Calcium Sandoz）大于奥斯钙（Os-Cal）大于奥索潘（Ossopan）。4种制剂在甲状旁腺激素（PTH）和尿羟脯氨酸水平变化方面无显著差异。因此，对每个受试者的4次结果进行了平均。钙负荷后，平均PTH从0.16±0.01微克/升降至0.10±0.02微克/升（p<0.001），尿羟脯氨酸/肌酐比值从20±1降至17±1（p<0.02），提示骨吸收对膳食钙摄入量立即产生反应。尿钠排泄增加，且与钙吸收指标相关（r = 0.63，p<0.01），但与钙制剂中的钠含量无关。这种效应可能很重要，尤其是对钠摄入量处于临界值的老年患者。
