Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi City, XinJiang Province, China.
Guangdong Second Provincial General Hospital, Guangzhou City, Guangdong Province, China.
Exp Gerontol. 2021 Nov;155:111581. doi: 10.1016/j.exger.2021.111581. Epub 2021 Oct 8.
Aerobic exercise plays an important role in prevention and treatment of atherosclerosis. Inflammatory response is the main pathological process during occurrence and development stage of atherosclerosis. SESNs are considered as anti-inflammation protein in atherosclerosis. In current study, a high expression level of SESN1 is identified under the condition of aerobic exercise, further investigation shows levels of IL-1β/IL-6/TNF-α are significantly suppressed compared to those atherosclerosis mice with no aerobic training. Besides, we find that the activation of NF-κB signaling is impeded. Combine with our previous study, SESN1 is considered as the downstream factor of aerobic exercise which tend to inhibit the activation of inflammatory signaling and results in suppressing the expression level of inflammatory factors. Another exciting finding is that MMP9/13 are also suppressed，but the potential mechanism is unclear. Overall, present study sheds light on the significance of aerobic exercise for inflammation and stability of plaque through SESN1 may help developing new clinical treatments of atherosclerosis.
有氧运动在动脉粥样硬化的预防和治疗中起着重要作用。炎症反应是动脉粥样硬化发生和发展阶段的主要病理过程。SESNs 被认为是动脉粥样硬化中的抗炎蛋白。在本研究中，发现有氧运动条件下 SESN1 的表达水平升高，进一步的研究表明，与未经有氧训练的动脉粥样硬化小鼠相比，IL-1β/IL-6/TNF-α 的水平显著降低。此外，我们发现 NF-κB 信号的激活受到抑制。结合我们之前的研究，SESN1 被认为是有氧运动的下游因子，它倾向于抑制炎症信号的激活，从而抑制炎症因子的表达水平。另一个令人兴奋的发现是 MMP9/13 也受到抑制，但潜在的机制尚不清楚。总的来说，本研究通过 SESN1 阐明了有氧运动对炎症和斑块稳定性的重要性，这可能有助于开发动脉粥样硬化的新的临床治疗方法。
